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Randomized controlled trial by A/Prof Jennifer Craig from Auckland University in New Zealand:

Authors

Author 1

CRAIG JP
Department of Ophthalmology (Auckland)

Author 2

TURNBULL PR
Department of Ophthalmology (Auckland)

Author 3

CHEN A
Department of Ophthalmology (Auckland)
Department of Optometry and Vision Science (Auckland)

Abstract

Purpose

To evaluate the effect of intense pulsed light (IPL) applied to the periocular area for meibomian gland dysfunction (MGD) in a prospective, double-masked, placebo-controlled, paired-eye study.

Methods

Twenty-eight participants (aged 45±16 years, 68% female) underwent IPL treatment (E>Eye, E-Swin, France), with homogeneously sequenced light pulses delivered to one eye (treated eye, randomised, masked), while placebo treatment was performed on the partner eye (control eye) on 3 occasions following baseline (BL) evaluation; on Day 1, Day 15, and Day 45. Lipid layer grade (LLG), non-invasive tear breakup time (NIBUT), tear evaporation rate (TER), tear meniscus height (TMH) and subjective symptom score (SPEED) were compared to BL and control values at each visit.

Results

LLG improved significantly from BL to Day 45 in the treated eye (p=0.0002), but not control eye (p=0.714) with an increase of 1.5 grades exhibited by 75% of treated eyes by Day 45. NIBUT also improved significantly from BL to Day 45 in the treated (p<0.0001), but not control eye (p=0.056). NIBUT in the treated eye was significantly longer than that in the control eye at Day 45 (14.1 ± 9.8s vs 8.6 ± 8.2s, p<0.0001). TER was not significantly lower at Day 45 compared to BL in the control eye (p=0.165), but approached significance in the treated eye (p = 0.080). No change in TMH was noted from BL in either eye at Day 45 (p>0.05). SPEED scores improved at each visit in both the treated (p<0.0001) and control eye (p=0.002), with 86% of participants noting reduced symptoms in the treated eye by Day 45.

Conclusions

IPL with multiple sculpted pulses shows therapeutic potential for MGD, statistically and clinically improving tear film quality and reducing symptoms of dry eye.

 

Clinical study by Dr Christian Malbrel, Ophthalmologist from Reims in France

A clinical study has been undertaken in France in 2012 by Doctor Christian MALBREL, Ophthalmologist and former director of studies at the Reims Faculty of Medicine to test the efficiency of the E>Eye.

The clinical study is called  TREATMENT WITH A POLYCHROMATIC PULSED LIGHT DEVICE FOR A DYSFUNCTION DESCRIBED AS “DRY EYE” IN THE FORM OF A CORNEAL CONDITION ASSOCIATED WITH A DEFICIENCY IN THE LIPID LAYER 

"The study has been realised over 80 patients aged between 21 and 90 years, with an average age of 67, with no preselection and representative of the “standard” patient register of an independent practice. 

The results show a significant subjective improvement, with satisfaction of the order of 90% following the first two treatment sessions. This improvement is established on the basis of the patient’s opinion of the discomfort experienced before and after the application of treatment and the associated focusing time, whether for reading or for work on a VDU. After the first treatment, this improvement is experienced for a number of days, and will only become more prolonged after the second and subsequent treatments."

The whole clinical study and the detailed results are available on request only. Please send an email at info@dry-eyes.com.au for more information.